In this second film adaptation of Richard Mathesons science-fiction novel (the first version being The Last Man on Earth with Vincent Price), Charlton Heston is Robert Neville, the sole normal survivor in a Los Angeles of a blighted future world of 1976, following germ warfare between Russia and China. Neville lives in a fancy L.A. penthouse, preserving a more-valuable-that-life-itself serum. During the day, he roams through the decimated city. At night, he fends off a bloodthirsty horde of mutant scavengers garbed in Spanish inquisition robes and Ray Ban shades, led by Matthias (Anthony Zerbe), a former television newscaster in his good ol pre-mutant days. Matthias and his half-human vampires want to get at the serum that Neville has so preciously squirreled away. Nevilles last man on earth status is shattered when he comes across a group of young people, presided over by the sexy and cynical Lisa (Rosalind Cash). Neville begins to form an interest in her, but Matthias minions keep both peace and love at bay. ~ Paul Brenner, All Movie Guide